NSC59984
Cat. No.：YN270387
CAS No. ：803647-40-7
| 产品名称: | NSC59984 |
| CAS No.: | 803647-40-7 |
| Chemical Name: | 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one |
| Synonyms: | NSC-59984,NSC 59984 |
| 分子量: | 265.27 |
| 分子式: | C₁₂H₁₅N₃O₄ |
| SMILES: | O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC59984 通过 MDM2 和泛素-蛋白酶体途径而诱导突变型 p53 蛋白降解。NSC59984 靶向 GOF 突变体 p53，并刺激 p73 恢复 p53 途径的信号传导。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhang, S., Zhou, L., Hong, B., et al.Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53Cancer Res.75(18),3842-3852(2015)
