AZD8330
Cat. No.：YN350100
CAS No. ：869357-68-6
| 产品名称: | AZD8330 |
| CAS No.: | 869357-68-6 |
| Chemical Name: | 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide |
| Synonyms: | ARRY-424704; ARRY-704 |
| 分子量: | 461.23 |
| 分子式: | C₁₆H₁₇FIN₃O₄ |
| SMILES: | IC1=CC(F)=C(C=C1)NC(N2C)=C(C=C(C2=O)C)C(NOCCO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD8330 (ARRY-424704) 是一种有效的非竞争性的MEK1/MEK2抑制剂，IC50为 7 nM。 |
| IC50和靶点: | [{name:"MEK1:7 nM (IC50)"},{name: "MEK2:7 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Baranski, Z., Booij, T.H., Kuijjer, M.L., et al.MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylationGenes Cancer6(11-12),503-512(2015)
Cohen, R.B., Aamdal, S., Nyakas, M., et al.A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignanciesEur. J. Cancer49(7),1521-1529(2013)
