Binimetinib
Cat. No.：YN350155
CAS No. ：606143-89-9
| 产品名称: | Binimetinib |
| CAS No.: | 606143-89-9 |
| Chemical Name: | 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide |
| Synonyms: | MEK162; ARRY-162; ARRY-438162 |
| 分子量: | 441.23 |
| 分子式: | C₁₇H₁₅BrF₂N₄O₃ |
| SMILES: | BrC1=CC=C(C(F)=C1)NC2=C(C3=C(C=C2C(NOCCO)=O)N(C=N3)C)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Binimetinib (MEK162) 是口服和选择性的MEK1/2抑制剂， Binimetinib (MEK162) 抑制MEK，IC50为 12 nMIC50。 |
| IC50和靶点: | [{name:"MEK:12 nM (IC50)'}, 'Autophagy'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yamaguchi, T., Kakefuda, R., Tajima, N., et al.Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivoInt. J. Oncol.39(1),23-31(2011)
