Cobimetinib
Cat. No.：YN350129
CAS No. ：934660-93-2
| 产品名称: | Cobimetinib |
| CAS No.: | 934660-93-2 |
| Chemical Name: | [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-methanone |
| Synonyms: | 考比替尼; GDC-0973; XL518 |
| 分子量: | 531.31 |
| 分子式: | C₂₁H₂₁F₃IN₃O₂ |
| SMILES: | OC1([C@H]2NCCCC2)CN(C1)C(C3=C(C(F)=C(C=C3)F)NC4=C(C=C(C=C4)I)F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cobimetinib (GDC-0973, RG7420) 是有效，选择性，可口服的MEK1抑制剂，抑制MEK1的IC50为4.2 nM。 |
| IC50和靶点: | [{name:"MEK1:4.2 nM (IC50)"}] |
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| Solvent & Solubility: |
Akinleye, A., Furgan, M., Mukhi, N., et al.MEK and the inhibitors: From bench to bedsideJ. Hematol. Oncol.6,27(2013)
Hoeflich, K.P., Merchang, M., Orr, C., et al.Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibitionCancer Res.72(1),210-219(2012)
Medina, T.M., and Lewis, K.D.The evolution of combined molecular targeted therapies to advance the therapeutic efficacy in melanoma: A highlight of vemurafenib and cobimetinibOnco Targets Ther.9,3739-3752(2016)
Sing, A., Ruan, Y., Tippett, T., et al.Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cellsJ. Exp. Clin. Cancer Res.34(1),104(2015)
