Valproic acid sodium salt
Cat. No.：YN380029
CAS No. ：1069-66-5
| 产品名称: | Valproic acid sodium salt |
| CAS No.: | 1069-66-5 |
| Chemical Name: | 2-propyl-pentanoic acid, monosodium salt |
| Synonyms: | 丙戊酸钠; Sodium Valproate |
| 分子量: | 166.19 |
| 分子式: | C₈H₁₅NaO₂ |
| SMILES: | O=C(O[Na])C(CCC)CCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Valproic acid sodium salt (Sodium Valproate) 是一种HDAC抑制剂，IC50值为 0.5-2 mM，抑制HDAC1的活性，(IC50，400 μM)，同时可诱导HDAC2的降解。Valproic acid sodium salt 激活Notch1信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid sodium salt 可用于癫痫、双相情感障碍和偏头痛等的研究。 |
| IC50和靶点: | [{name:"HDAC1:400 μM (IC50)"},{name: "HDAC:0.5-2 mM (IC50)'}, 'HDAC2', 'Autophagy', 'Mitophagy'] |
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Qing, H., He, G., Ly, P.T., et al.Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsJ. Exp. Med.205(12),2781-2789(2008)
Elmazar, M.M., Hauck, R.S., and Nau, H.Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidJ. Pharm. Sci.82(12),1255-1258(1993)
