LY-411575

Cat. No.：YN380140

CAS No. ：209984-57-6

产品名称:	LY-411575
CAS No.:	209984-57-6
Chemical Name:	N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-αS-hydroxy-benzeneacetamide
Synonyms:	LY411575
分子量:	479.48
分子式:	C₂₆H₂₃F₂N₃O₄
SMILES:	O=C1[C@@H](NC([C@@H](NC([C@H](C2=CC(F)=CC(F)=C2)O)=O)C)=O)C3=CC=CC=C3C(C=CC=C4)=C4N1C
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	LY-411575 是高效的γ-secretase抑制剂，能够抑制 Aβ40 蛋白的产生，其IC50值为 0.078 nM/0.082 nM（基于膜/细胞），同时抑制 Notch 分裂，IC50值为 0.39 nM。
IC50和靶点:
In Vitro:
In Vivo:
Clinical Trial:
Solvent & Solubility:

Czirr, E., Leuchtenberger, S., Dorner-Ciossek, C., et al.Insensitivity to Aβ42-lowering nonsteroidal anti-inflammatory drugs and γ-secretase inhibitors is common among aggressive presenilin-1 mutationsJ. Biol. Chem.282(34),24504-24513(2007)
Curry, C.L., Reed, L.L., Golde, T.E., et al.Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cellsOncogene24(42),6333-6344(2005)
Okamoto, R., Tsuchiya, K., Nemoto, Y., et al.Requirement of Notch activation during regeneration of the intestinal epitheliaAm. J. Physiol. Gastrointest. Liver Physiol.296(1),G23-G35(2009)
Abranches, E., Silva, M., Pradier, L., et al.Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryoPLoS One4(7),e6286(2009)