Bryostatin 1
Cat. No.：YN310074
CAS No. ：83314-01-6
| 产品名称: | Bryostatin 1 |
| CAS No.: | 83314-01-6 |
| Chemical Name: | (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4 |
| Synonyms: | 苔藓抑素1 |
| 分子量: | 905.03 |
| 分子式: | C₄₇H₆₈O₁₇ |
| SMILES: | O[C@]12[C@H](/C(C[C@](C[C@](OC(C[C@@H](C[C@@]3([H])O[C@](O)(C(C)([C@@H](OC(C)=O)C3)C)C[C@@](C/4)([H])O[C@@](CC4=C/C(OC)=O)([H])/C=C/C2(C)C)O)=O)([H])[C@H](O)C)([H])O1)=C/C(OC)=O)OC(/C=C/C=C/CCC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bryostatin 1 是一种天然的大环内酯类化合物，从苔藓虫Bugula neritina中分离出来，也是一种有效的中枢神经系统 (CNS) 渗透性的PKC调节剂。Bryostatin 1 以Ki值为 8.07 nM 和 0.45 nM 分别结合到分离的 Munc13-1 的 C1 域和全长的 Munc13-1 蛋白。Bryostatin 1 具有抗癌，抗炎，神经保护，抗HIV-1感染的特性。 |
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Abramson, E., Hardman, C., Shimizu, A.J., et al.Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammationCell. Chem. Biol.28(4),537-545(2021)
Kortmansky, J., and Schwartz, G.K.Bryostatin-1: A novel PKC inhibitor in clinical developmentCancer Invest.21(6),924-936(2003)
Hany, L., Turmel, M.-O., Barat, C., et al.Bryostatin-1 decreases HIV-1 infection and viral production in human primary macrophagesJ. Virol.96(4),e0195321(2022)
Kornberg, M.D., Smith, M.D., Shirazi, H.A., et al.Bryostatin-1 alleviates experimental multiple sclerosisProc. Natl. Acad. Sci. U.S.A.115(9),2186-2191(2018)
Lucke-Wold, B.P., Logsdon, A.F., Smith, K.E., et al.Bryostatin-1 restores blood brain barrier integrity following blast-induced traumatic brain injuryMol. Neurobiol.52(3),1119-1134(2015)
