Daphnetin
Cat. No.：YN310343
CAS No. ：486-35-1
| 产品名称: | Daphnetin |
| CAS No.: | 486-35-1 |
| Chemical Name: | 7,8-dihydroxy-2H-1-benzopyran-2-one |
| Synonyms: | 瑞香素; 7,8-Dihydroxycoumarin |
| 分子量: | 178.14 |
| 分子式: | C₉H₆O₄ |
| SMILES: | O=C1C=CC2=CC=C(O)C(O)=C2O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Daphnetin (7,8-dihydroxycoumarin) 是从Genus Daphne中分离得到的一种香豆素衍生物，是一种蛋白酶 (protein kinase) 抑制剂，对 EGFR、PKA 和 PKC 的IC50值分别为 7.67 μM、9.33 μM 和 25.01 μM。Daphnetin (7,8-dihydroxycoumarin) 是用于抗炎、抗过敏疾病的植物次生代谢产物药物，可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究，具有抗疟疾、解热等特性。 |
| IC50和靶点: | [{name:"EGFR:7.67 μM (IC50)'}, 'Plasmodium', {'PKA:9.33 μM (IC50)"},{name: "PKC:25.01 μM (IC50)"}] |
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Yang, E.B., Zhao, Y.N., Zhang, K., et al.Daphnetin, one of coumarin derivatives, is a protein kinase inhibitorBiochem. Biophys. Res. Commun.260(3),682-685(1999)
Jiménez-Orozco, F.A., Rosales, A.A., Vega-López, A., et al.Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicityEur. J. Pharmacol.668(1-2),35-41(2011)
Lv, H., Liu, Q., Zhou, J., et al.Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell deathFree Radic. Biol. Med.106,38-52(2017)
