IN-1130
Cat. No.：YN460036
CAS No. ：868612-83-3
| 产品名称: | IN-1130 |
| CAS No.: | 868612-83-3 |
| Chemical Name: | 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide; 3-[[4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide; |
| Synonyms: | IN1130;IN 1130 |
| 分子量: | 420.47 |
| 分子式: | C25H20N6O |
| SMILES: | NC(C1C=CC=C(CC2NC(C3=CC=CC(C)=N3)=C(C3C=CC4=NC=CN=C4C=3)N=2)C=1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N-1130 是一种高度选择性的转化生长因子-β I 型受体激酶 (ALK5) 抑制剂，对ALK5介导的Smad3磷酸化的IC50为 5.3 nM。IN-1130 抑制酪蛋白的ALK5磷酸化 (IC50=36 nM)，抑制p38α丝裂原活化的蛋白激酶 (IC50=4.3 μM)。IN-1130 可抑制阻塞性肾病中的肾纤维化，阻止乳腺癌的肺转移。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Moon, J., et al.: Kidney Int., 70, 1234 (2006)
