Desmethylglycitein
Cat. No.：YN310365
| 产品名称: | Desmethylglycitein |
| CAS No.: | 17817-31-1 |
| Chemical Name: | 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Synonyms: | 4',6,7-三羟基异黄酮; 4',6,7-Trihydroxyisoflavone |
| 分子量: | 270.24 |
| 分子式: | C₁₅H₁₀O₅ |
| SMILES: | O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(O)C=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desmethylglycitein (4',6,7-Trihydroxyisoflavone)，大豆苷元的代谢产物，来源于大豆Glycine max，具有抗氧化性和抗癌活性。Desmethylglycitein 在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线 (sUV) 诱导的基质金属蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 竞争 |
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Lee, D.E., Lee, K.W., Jung, S.K., et al.6,7,4'-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2Carcinogenesis32(4),629-635(2011)
Seo, S.G., Yang, H., Shin, S.H., et al.A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3KMol. Nutr. Food Res.57(8),1446-1455(2013)
Ko, Y.-H., Kim, S.Y., Lee, S.-Y., et al.6,7,4'-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in miceEur. J. Pharmacol.826,140-147(2018)
Kim, E.-N., Kim, Y.G., Lee, J.-H., et al.6,7,4'-Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivoPhytother. Res.33(11),2948-2959(2019)
