K-252c
Cat. No.：YN310369
| 产品名称: | K-252c |
| CAS No.: | 85753-43-1 |
| Chemical Name: | 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one |
| Synonyms: | staurosporine aglycone; K252c; SD 1825; SD-1825; SD1825; |
| 分子量: | 311.34 |
| 分子式: | C₂₀H₁₃N₃O |
| SMILES: | O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | K-252c，一种十字孢碱的类似物，可从Nocardiopsis sp.中分离得到，是一种能透过细胞的、PKC的抑制剂，IC50值为2.45 µM。K-252c可诱导人慢性粒细胞白血病癌细胞凋亡。K-252c还能抑制β内酰胺酶、胰凝乳蛋白酶和苹果酸脱氢酶。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Pereira, E.R., Belin, L., Sancelme, M., et al.Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial propertiesJ. Med. Chem.39(22),4471-4477(1996)
Liu, R., Zhu, T., Li, D., et al.Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2Arch. Pharm. Res.30(3),270-274(2007)
Zimmermann, A., Wilts, H., Lenhardt, M., et al.Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinaseAntiviral Res.48(1),49-60(2000)
McGovern, S.L., and Shoichet, B.K.Kinase inhibitors: Not just for kinases anymoreJ. Med. Chem.46(8),1478-1483(2003)
