DCP-LA
Cat. No.：YN310093
CAS No. ：28399-31-7
| 产品名称: | DCP-LA |
| CAS No.: | 28399-31-7 |
| Chemical Name: | 2-[(2-pentylcyclopropyl)methyl]-cyclopropaneoctanoic acid |
| Synonyms: | FR236924 |
| 分子量: | 308.50 |
| 分子式: | C₂₀H₃₆O₂ |
| SMILES: | O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DCP-LA (FR236924) 是一种亚油酸衍生物，选择性地激活PKCε。 |
| IC50和靶点: | |
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Kanno, T., Yamamoto, H., Yaguchi, T., et al.The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding siteJ. Lipid. Res.47(6),1146-1156(2006)
Nelson, T.J., Cui, C., Luo, Y., et al.Reduction of β-amyloid levels by novel protein kinase Cϵ activatorsJ. Biol. Chem.284(50),34514-34521(2009)
Shimizu, T., Kanno, T., Tanaka, A., et al.α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomersCell Physiol. Biochem.27(2),149-158(2011)
Hongpaisan, J., Sun, M.-K., and Alkon, D.L.PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic miceJ. Neurosci.31(2),630-643(2011)
