Ro 32-0432 hydrochloride
Cat. No.：YN310095
CAS No. ：1781828-85-0
| 产品名称: | Ro 32-0432 hydrochloride |
| CAS No.: | 1781828-85-0 |
| Chemical Name: | 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride; (S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole |
| Synonyms: | |
| 分子量: | 489.01 |
| 分子式: | C₂₈H₂₉ClN₄O₂ |
| SMILES: | O=C(C(C1=C(C[C@@H](CN(C)C)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 32-0432 hydrochloride 是一种有效的，选择性的，ATP 竞争性和具有口服活性的PKC抑制剂，对PKCα，PKCβI，PKCβII，PKCγ和PKCε的IC50值分别为 9.3 nM，28 nM，30 nM，36.5 nM 和 108.3 nM。Ro 32-0432 hydrochloride 也是一种选择性GRK5的抑制剂。Ro 32-0432 hydrochloride 可防止 T 细胞活化，并可用于慢性炎症和自身免疫性疾病的研究。 |
| IC50和靶点: | [{name:"PKCα:9.3 nM (IC50)"},{name: "PKC-βI:28 nM (IC50)"},{name: "PKC-βII:30 nM (IC50)"},{name: "PKCγ:36.5 nM (IC50)"},{name: "PKCε:108.3 nM (IC50)'}, 'G protein-coupled receptor kinase 5 (GRK5)'] |
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Wilkinson, S. E., et al.: Biochem. J., 294, 335 (1993)
Matsumoto, T., et al.: J. Immunol., 191, 2247 (2013)
Henriksson, M., et al.: BMC Neurosci., 8, (2007)
