CGP60474
Cat. No.：YN310105
CAS No. ：164658-13-3
| 产品名称: | CGP60474 |
| CAS No.: | 164658-13-3 |
| Chemical Name: | 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol |
| Synonyms: | CGP-60474; CGP 60474 |
| 分子量: | 355.82 |
| 分子式: | C₁₈H₁₈ClN₅O |
| SMILES: | ClC1=CC(NC2=NC=CC(C3=CC=NC(NCCCO)=C3)=N2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP60474 是一种高效的抗内毒素药物，是一种有效的细胞周期蛋白依赖激酶(CDK)抑制剂 (CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50值分别为 26、3、4、216、10、200 和 13 nM)。CGP60474 是一种选择性和 ATP 竞争性PKC抑制剂。 |
| IC50和靶点: | [{name:"CDK1-Cyclin B:26 nM (IC50)"},{name: "CDK2/cyclinE:3 nM (IC50)"},{name: "cdk2/cyclin A:4 nM (IC50)"},{name: "CDK4/cyclin D:216 nM (IC50)"},{name: "Cdk5/p25:10 nM (IC50)"},{name: "CDK7/cyclin H:200 nM (IC50)"},{name: "CDK9/cycT:13 nM (IC50)'}, 'PKC'] |
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| Solvent & Solubility: |
Ruetz, S., Fabbro, D., Zimmermann, J., et al.Chemical and biological profile of dual Cdk1 and Cdk2 inhibitorsCurr. Med. Chem. Anticancer Agents3(1),1-14(2003)
Han, H.-W., Hahn, S., Jeong, H.Y., et al.LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agentSci. Rep.8(1),14969(2018)
