VTX-27
Cat. No.：YN310134
CAS No. ：1321924-70-2
| 产品名称: | VTX-27 |
| CAS No.: | 1321924-70-2 |
| Chemical Name: | (αR,2S)-4-[3-chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridin-3-yl)-2-pyridinyl]-α-methyl-α-(1-methylethyl)-2-piperazinemethanol |
| Synonyms: | VTX27，VTX 27 |
| 分子量: | 418.90 |
| 分子式: | C₂₀H₂₄ClFN₆O |
| SMILES: | FC1=C(N=C(N2C[C@@](NCC2)([H])[C@](C)(O)C(C)C)C(Cl)=C1)C3=NNC4=NC=CC=C34 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VTX-27 是蛋白激酶 C θ(PKC θ)的选择性抑制剂，其对 PKC θ 和 PKC δ 的Ki值分别为 0.08 nM 和 16 nM。 |
| IC50和靶点: | [{name:"PKCθ:0.08 nM (Ki)"},{name: "PKCδ:16 nM (Ki)"},{name: "PKCα:356 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jimenez, J.-M., Boyall, D., Brenchley, G., et al.Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseasesJ. Med. Chem.56(5),1799-1810(2013)
