A-3 hydrochloride
Cat. No.：YN310181
CAS No. ：78957-85-4
规格
价格(RMB)
库存
| 产品名称: | A-3 hydrochloride |
| CAS No.: | 78957-85-4 |
| Chemical Name: | A-3; |
| Synonyms: | A3 HCl |
| 分子量: | 321.22 |
| 分子式: | C₁₂H₁₄Cl₂N₂O₂S |
| SMILES: | O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-3 hydrochloride 是靶向多种激酶 (kinase) 的强效、细胞渗透的、可逆的、ATP 竞争性的非选择性拮抗剂。A-3 hydrochloride 是针对 PKA (Ki=4.3 µM)，酪蛋白激酶 II (Ki=5.1 µM) 和肌球蛋白轻链激酶 (MLCK) (Ki=7.4 µM) 的抑制剂。A-3 hydrochloride 还抑制 PKC 和酪蛋白激酶 I 的活性，Ki分别为 47 µM 和 80 µM。 |
| IC50和靶点: | [{name:"CK1:80 μM (Ki)"},{name: "CK2:5.1 μM (Ki)"},{name: "PKC:47 μM (Ki)"},{name: "PKA:4.3 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Inagaki, M., et al.: Mol. Pharmacol., 29, 577 (1986)
