Bisindolylmaleimide VIII acetate
Cat. No.：YN310202
CAS No. ：138516-31-1
| 产品名称: | Bisindolylmaleimide VIII acetate |
| CAS No.: | 138516-31-1 |
| Chemical Name: | 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, acetate |
| Synonyms: | Ro 31-7549 acetate; Bis VIII acetate |
| 分子量: | 458.51 |
| 分子式: | C₂₆H₂₆N₄O₄ |
| SMILES: | O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) 是一种有效的选择性蛋白激酶 C (PKC) 抑制剂，对大鼠脑 PKC 的IC50为 158 nM。Bisindolylmaleimide VIII acetate 对 PKC-α，PKC-βI，PKC-βII，PKC-γ，PKC-ε 的 IC50分别为 53、195、163、213 和 175 nM。Bisindolylmaleimide VIII acetate 促进 Fas 介导的细胞凋亡 ( |
| IC50和靶点: | [{name:"Rat Brain PKC:158 nM (IC50)"},{name: "PKC-α:53 nM (IC50)"},{name: "PKC-βI:195 nM (IC50)"},{name: "PKC-βII:163 nM (IC50)"},{name: "PKC-γ:213 nM (IC50)"},{name: "PKC-ε:175 nM (IC50)"}] |
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