PKCβ inhibitor 1
Cat. No.：YN310213
CAS No. ：257879-35-9
| 产品名称: | PKCβ inhibitor 1 |
| CAS No.: | 257879-35-9 |
| Chemical Name: | 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-1H-pyrrole-2,5-dione |
| Synonyms: | KUN79359 |
| 分子量: | 411.46 |
| 分子式: | C₂₄H₂₁N₅O₂ |
| SMILES: | O=C(C(C1=CN(CCCN2C=CN=C2)C3=C1C=CC=C3)=C4NC5=CC=CC=C5)NC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PKCβ inhibitor 1 是有效的，ATP 竞争性和选择性PKCβ抑制剂，对人 PKCβ1 和 PKCβ2 的IC50分别为 21 和 5 nM。与 PKCβ2 相比，PKCβ inhibitor 1 对其他 PKC 同工酶 (PKCα、PKCγ 和 PKCε) 具有 60 倍以上的选择性。 |
| IC50和靶点: | [{name:"human PKCβ1:21 nM (IC50)"},{name: "human PKCβ2:5 nM (IC50)"},{name: "PKCα:331 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Tanaka, M., Sagawa, S., Hoshi, J.-I., et al.Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitorsBioorg. Med. Chem. Lett.14(20),5171-5174(2004)
McDonnell, M.E., Bian, H., Wrobel, J., et al.Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitorsBioorg. Med. Chem. Lett.24(4),1116-1121(2014)
Saba, N.S., and Levy, L.S.Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cellsJ. Investig. Med.60(1),29-38(2012)
