Bisindolylmaleimide I
Cat. No.：YN310251
CAS No. ：133052-90-1
| 产品名称: | Bisindolylmaleimide I |
| CAS No.: | 133052-90-1 |
| Chemical Name: | 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Synonyms: | GF109203X; Go 6850 |
| 分子量: | 412.48 |
| 分子式: | C₂₅H₂₄N₄O₂ |
| SMILES: | O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide I (GF109203X) 是一种高度选择，可渗透细胞，可逆的PKC抑制剂，Ki值为14 nM。 |
| IC50和靶点: | [{name:"Bovine brain PKC:10 nM (IC50)"},{name: "PKCβII:16 nM (IC50)"},{name: "PKCβI:17 nM (IC50)"},{name: "PKCα:20 nM (IC50)"},{name: "PKCγ:20 nM (IC50)"},{name: "FDGFR:65 μM (IC50)"}] |
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Toullec, D., Pianetti, P., Coste, H., et al.The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CJ. Biol. Chem.266(24),15771-15781(1991)
Hers, I., Tavaré, J.M., and Denton, R.M.The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activityFEBS Lett.460(3),433-436(1999)
Coultrap, S.J., Sun, H., Tenner, T.E., et al.Competitive antagonism of the mouse 5-hydroxytryptamine receptor by bisindolylmaleimide I, a "selective" protein kinase C inhibitorJ. Pharmacol. Exp. Ther.290(1),76-82(1999)
