Afuresertib
Cat. No.：YN310279
CAS No. ：1047644-62-1
| 产品名称: | Afuresertib |
| CAS No.: | 1047644-62-1 |
| Chemical Name: | |
| Synonyms: | GSK2110183 |
| 分子量: | 427.32 |
| 分子式: | C₁₈H₁₇Cl₂FN₄OS |
| SMILES: | O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[C@@H](CC3=CC=CC(F)=C3)CN |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Afuresertib (GSK2110183) 是一个口服有效的，ATP 竞争性的选择性 pan-Akt 抑制剂，作用于 Akt1/Akt2/Akt3，Ki值分别为 0.08/2/2.6 nM。 |
| IC50和靶点: | [{name:"Akt2:2 nM (Ki)"},{name: "Akt3:2.6 nM (Ki)"},{name: "Akt1 E17K mutant:0.2 nM (IC50)"},{name: "PKCη:210 nM (IC50)"},{name: "PKC-βI:430 nM (IC50)"},{name: "PKCθ:510 nM (IC50)"},{name: "ROCK:100 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
