Phorbol 12-myristate 13-acetate
Cat. No.：YN310308
CAS No. ：16561-29-8
| 产品名称: | Phorbol 12-myristate 13-acetate |
| CAS No.: | 16561-29-8 |
| Chemical Name: | tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester |
| Synonyms: | PMA |
| 分子量: | 616.83 |
| 分子式: | C₃₆H₅₆O₈ |
| SMILES: | CCCCCCCCCCCCCC(O[C@H]([C@H]1C)[C@]2(OC(C)=O)[C@@]([C@@](C=C(CO)C[C@]34O)([H])[C@@]1(O)[C@]4([H])C=C(C)C3=O)([H])C2(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phorbol 12-myristate 13-acetate (PMA) 是一种佛波酯，是蛋白激酶 C(PKC)和SphK的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。 |
| IC50和靶点: | [{name:"PKC:11.7 nM (EC50)'}, 'NF-κB'] |
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| Solvent & Solubility: |
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Hellweg, C.E., Arenz, A., Bogner, S., et al.Activation of nuclear factor κB by different agents: Influence of culture conditions in a cell-based assayAnn. N. Y. Acad. Sci.1091,191-204(2006)
Lund, M.E., To, J., O'Brien, B.A., et al.The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulusJ. Immunol. Methods430,64-70(2016)
Petretto, A., Bruschi, M., Pratesi, F., et al.Neutrophil extracellular traps (NET) induced by different stimuli: A comparative proteomic analysisPLoS One14(7),e0218946(2019)
Vähätupa, M., Pemmari, T., Junttila, I., et al.Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)J. Vis. Exp.,154(2019)
