Bufuralol hydrochloride
Cat. No.：YN320279
| 产品名称: | Bufuralol hydrochloride |
| CAS No.: | 60398-91-6 |
| Chemical Name: | α-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol, monohydrochloride |
| Synonyms: | Ro 3-4787 hydrochloride |
| 分子量: | 297.82 |
| 分子式: | C₁₆H₂₄ClNO₂ |
| SMILES: | OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bufuralol hydrochloride (Ro 3-4787 hydrochloride) 是一种有效的非选择性，具有口服活性的 β-肾上腺素受体 (β-adrenoreceptor) 拮抗剂，具有部分激动剂活性。Bufuralol hydrochloride 是一种 CYP2D6 探针的底物。 |
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Narimatsu, S., Takemi, C., Kuramoto, S., et al.Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450sChirality15(4),333-339(2003)
Pringle, T.H., Francis, R.J., East, P.B., et al.Pharmacodynamic and pharmacokinetic studies on bufuralol in manBr. J. Clin. Pharmac.22(5),527-534(1986)
Blaber, L.C., Burden, D.T., Eigenmann, R., et al.The effects of bufuralol, a β-adrenoceptor antagonist with predominant β2-adrenoceptor agonistic activity, in the cat and the dogJ. Cardiovasc. Pharmacol.6(1),165-175(1984)
Yamazaki, H., Guo, Z., Persmark, M., et al.Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomesMol. Pharmacol.46(3),568-577(1994)
Paine, M.J.I., Gilham, D., Roberts, G.C.K., et al.Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systemsArch. Biochem. Biophys.328(1),143-150(1996)
Chen, N., Cui, D., Wang, Q., et al.In vitro drug-drug interactions of budesonide: Inhibition and induction of transporters and cytochrome P450 enzymesXenobiotica48(6),637-646(2018)
