Lanifibranor
Cat. No.：YN290060
CAS No. ：927961-18-0
| 产品名称: | Lanifibranor |
| CAS No.: | 927961-18-0 |
| Chemical Name: | 1-(6-benzothiazolylsulfonyl)-5-chloro-1H-indole-2-butanoic acid |
| Synonyms: | IVA337 |
| 分子量: | 434.92 |
| 分子式: | C₁₉H₁₅ClN₂O₄S₂ |
| SMILES: | O=C(O)CCCC(N1S(=O)(C2=CC=C3N=CSC3=C2)=O)=CC4=C1C=CC(Cl)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lanifibranor 是一种泛过氧化物酶体增殖物激活受体 (PPAR) 的激动剂，对人类PPARα，PPARσ和PPARγ的EC50值分别为 1.5, 0.87 和 0.21 μM。 |
| IC50和靶点: | [{name:"PPARγ:206 nM (EC50, Human PPARγ)"},{name: "PPARδ:866 nM (EC50, Human PPARδ)"},{name: "PPARα:1537 nM (EC50, Human PPARα)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Boubia, B., Poupardin, O., Barth, M., et al.Design, synthesis, and evaluation of a novel series of indole sulfonamide peroxisome proliferator activated receptor (PPAR) α/γ/δ triple activators: Discovery of lanifibranor, a new antifibrotic clinical candidateJ. Med. Chem.61(6),2246-2265(2018)
