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GW 6471

Cat. No.:YN290346

  • CAS No. :880635-03-0

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    • 产品名称: GW 6471
      CAS No.: 880635-03-0
      Chemical Name: N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-propanamide
      Synonyms:GW 6471
      分子量:619.67
      分子式:C₃₅H₃₆F₃N₃O₄
      SMILES:CCC(NC[C@@H](N/C(C)=C\C(C1=CC=C(C(F)(F)F)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: GW 6471 是一种有效的PPARα拮抗剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Kersten, S., Desvergne, B., and Wahli, W.Roles of PPARs in health and diseaseNature405(6785),421-424(2000)

      Tenenbaum, A., Motro, M., and Fisman, E.Z.Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessonsCardiovasc. Diabetol.4(14),1-5(2005)

      Ahmed, W., Ziouzenkova, O., Brown, J., et al.PPARs and their metabolic modulation: New mechanisms for transcriptional regulation?J. Intern. Med.262,184-198(2007)

      Xu, H.E., Stanley, T.B., Montana, V.G., et al.Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARαNature415(6873),813-817(2002)

      Wang, W., Lin, Q., Lin, R., et al.PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathwayExp. Cell Res.319(10),1523-1533(2013)

      Downer, E.J., Clifford, E., Amu, S., et al.The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-αJ. Biol. Chem.287(30),25440-25453(2012)

      Müller, M.Q., de Koning, L.I., Schmidt, A., et al.An innovative method to study target protein-drug interactions by mass spectrometryJ. Med. Chem.52(9),2875-2879(2009)

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