Pirinixic acid
Cat. No.：YN290411
CAS No. ：50892-23-4
| 产品名称: | Pirinixic acid |
| CAS No.: | 50892-23-4 |
| Chemical Name: | 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid |
| Synonyms: | Wy-14643 |
| 分子量: | 323.80 |
| 分子式: | C₁₄H₁₄ClN₃O₂S |
| SMILES: | O=C(O)CSC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pirinixic acid (Wy-14643) 是一种有效的PPARα激动剂，对鼠的PPARα和 PPARγ 的EC50值分别为 0.63 μM, 32 μM，对人的PPARα，PPARγ 和 PPARδ 的EC50值分别为 5.0 μM，60 μM，35 μM。 |
| IC50和靶点: | [{name:"PPARα:0.63 μM (EC50)"},{name: "PPARγ:32 μM (EC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al.Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugsJ. Biol. Chem.272(6),3406-3410(1997)
Azuma, Y.-T., Nishiyama, K., Matsuo, Y., et al.PPARα contributes to colonic protection in mice with DSS-induced colitisInt. Immunopharmacol.10(10),1261-1267(2010)
Ip, E., Farrell, G., Hall, P., et al.Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in miceHepatology39(5),(2004)
