Arhalofenate
Cat. No.：YN290319
| 产品名称: | Arhalofenate |
| CAS No.: | 24136-23-0 |
| Chemical Name: | 4-chloro-αR-[3-(trifluoromethyl)phenoxy]-benzeneacetic acid, 2-(acetylamino)ethyl ester |
| Synonyms: | 芳卤芬酯; MBX 102; JNJ 39659100 |
| 分子量: | 415.79 |
| 分子式: | C₁₉H₁₇ClF₃NO₄ |
| SMILES: | O=C(OCCNC(C)=O)[C@@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Arhalofenate (MBX 102) 是选择性的(PPAR)-γ部分激动剂，常用于 2 型糖尿病的研究。 |
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Gregoire, F.M., Zhang, F., Clarke, H.J., et al.MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edemaMol. Endocrinol.23(7),975-988(2009)
Chandalia, A., Clarke, H.J., Clemens, L.E., et al.MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activationPPAR Res.,706852(2009)
McWherter, C., Choi, Y.-J., Serrano, R.L., et al.Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signalingArthritis Res. Ther.20(1),204(2018)
