GW1929
Cat. No.：YN290360
CAS No. ：196808-24-9
| 产品名称: | GW1929 |
| CAS No.: | 196808-24-9 |
| Chemical Name: | N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine |
| Synonyms: | GW1929;(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid;(S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid;GW 1929 HYDROCHLORIDE;GW-1929;Lopac-G-5668;QCR-145;Tocris-1664;GW |
| 分子量: | 495.57 |
| 分子式: | C₃₀H₂₉N₃O₄ |
| SMILES: | O=C(O)[C@H](CC1=CC=C(C=C1)OCCN(C)C2=NC=CC=C2)NC3=CC=CC=C3C(C4=CC=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW1929是有效的PPAR-γ激动剂，对人PPAR-γ的pKi为8.84。对人和鼠的pEC50分别为8.56 和 8.27。 |
| IC50和靶点: | [{name:"PPAR-γ:8.56 (pEC50, Human PPAR-γ)"}] |
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| Solvent & Solubility: |
Yang, Q., and Li, Y.Roles of PPARs on regulating myocardial energy and lipid homeostasisJ. Mol. Biol.85,697-706(2007)
Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., et al.An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)J. Biol. Chem.270(22),12953-12956(1995)
Henke, B.R., Blanchard, S.G., Brackeen, M.F., et al.N-(2-Benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agentsJ. Med. Chem.41(25),5020-5036(1998)
Brown, K.K., Henke, B.R., Blanchard, S.G., et al.A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty ratDiabetes48(7),1415-1424(1999)
Kaundal, R.K., and Sharma, S.S.GW1929: A nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentationBehav. Brain Res.216(2),606-612(2011)
