1-Naphthyl PP1
Cat. No.：YN440299
CAS No. ：221243-82-9
| 产品名称: | 1-Naphthyl PP1 |
| CAS No.: | 221243-82-9 |
| Chemical Name: | 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | 1-NA-PP 1 |
| 分子量: | 317.39 |
| 分子式: | C₁₉H₁₉N₅ |
| SMILES: | CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-Naphthyl PP1 (1-NA-PP 1) 是一种选择性的src家族激酶抑制剂。1-Naphthyl PP1 抑制 v-Src 和 c-Fyn，c-Abl，CDK2 和CAMK II，IC50分别为 1.0，0.6，0.6，18 和 22 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bishop, A.C., Kung, C.y., Shah, K., et al.Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approachJ. Am. Chem. Soc.121(4),627-631(1999)
Bishop, A.C., Ubersax, J.A., Petsch, D.T., et al.A chemical switch for inhibitor-sensitive alleles of any protein kinaseNature407(6802),395-401(2000)
Endo, S., Satoh, Y., Shah, K., et al.A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivativesBiochem. Biophys. Res. Commun.341(1),261-265(2006)
Kenski, D.M., Zhang, C., von Zastrow, M., et al.Chemical genetic engineering of G protein-coupled receptor kinase 2J. Biol. Chem.280(41),35051-35061(2005)
