WH-4-023
Cat. No.：YN440203
CAS No. ：837422-57-8
规格
价格(RMB)
库存
| 产品名称: | WH-4-023 |
| CAS No.: | 837422-57-8 |
| Chemical Name: | N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid, 2,6-dimethylphenyl ester |
| Synonyms: | Dual LCK/SRC inhibitor |
| 分子量: | 568.67 |
| 分子式: | C₃₂H₃₆N₆O₄ |
| SMILES: | O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WH-4-023 是一种有效的选择性的Lck/Src抑制剂，IC50分别为 2 nM/6 nM，对p38α 和 KDR作用效果稍弱。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Martin, M.W., Newcomb, J., Nunes, J.J., et al.Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activityJ. Med. Chem.49(16),4981-4991(2006)
Moroco, J.A., Baumgartner, M.P., Rust, H.L., et al.A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding regionChem. Biol. Drug Des.86(2),144-155(2015)
Theunissen, T.W., Powell, B.E., Wang, H., et al.Systematic identification of culture conditions for induction and maintenance of naive human pluripotencyCell Stem Cell15(4),471-487(2014)
