A-770041
Cat. No.：YN440136
CAS No. ：869748-10-7
规格
价格(RMB)
库存
| 产品名称: | A-770041 |
| CAS No.: | 869748-10-7 |
| Chemical Name: | N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide |
| Synonyms: | A770041;A 770041 |
| 分子量: | 621.73 |
| 分子式: | C₃₄H₃₉N₉O₃ |
| SMILES: | NC1=C2C(N([C@@H]3CC[C@@H](N4CCN(C(C)=O)CC4)CC3)N=C2C5=CC=C(NC(C6=CC7=C(C=CC=C7)N6C)=O)C(OC)=C5)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-770041是口服活性Lck抑制剂，IC50为147 nM，作用于Lck的活性较Fyn和其它Src家族激酶高300倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Burchat, A., Borhani, D.W., Calderwood, D.J., et al.Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejectionBioorg. Med. Chem. Lett.16(1),118-122(2006)
Chang, H.W., Kanegasaki, S., Jin, F., et al.A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligandAllergy75(6),1371-1381(2020)
Stachlewitz, R.F., Hart, M.A., Bettencourt, B., et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejectionJ. Pharmacol. Exp. Ther.315(1),36-41(2005)
Li, L., Cui, Y., Shen, J., et al.Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1Leuk. Res.78,12-20(2019)
Duan, Z., Zhang, J., Ye, S., et al.A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cellsBMC Cancer14,681(2014)
