Saracatinib
Cat. No.：YN440067
CAS No. ：379231-04-6
规格
价格(RMB)
库存
| 产品名称: | Saracatinib |
| CAS No.: | 379231-04-6 |
| Chemical Name: | N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Synonyms: | 塞卡替尼; AZD0530 |
| 分子量: | 542.03 |
| 分子式: | C₂₇H₃₂ClN₅O₅ |
| SMILES: | ClC1=CC=C2C(OCO2)=C1NC3=C4C(OC5CCOCC5)=CC(OCCN6CCN(C)CC6)=CC4=NC=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Saracatinib (AZD0530) 是一种有效的Src抑制剂，抑制c-Src，Lck，c-YES，Lyn，Fyn，Fgr和Blk的IC50值为 2.7-11 nM，对其他酪氨酸激酶具有选择性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hennequin, L.F., Allen, J., Breed, J., et al.N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitorJ. Med. Chem.49(22),6465-6488(2006)
Allen, J.G., Fotsch, C., and Babij, P.Emerging targets in osteoporosis disease modificationJ. Med. Chem.53(11),4332-4353(2010)
Lee, K., Kim, J., Jeong, K.W., et al.Structure-based virtual screening of Src kinase inhibitorsBioorg. Med. Chem.17(8),3152-3161(2009)
Saad, F., and Lipton, A.SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancerCancer Treat. Rev.36(2),177-184(2010)
de Wispelaere, M., LaCroix, A.J., and Yang, P.L.The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via fyn kinaseJ. Virol.87(13),7367-7381(2013)
