1-NM-PP1
Cat. No.：YN440301
CAS No. ：221244-14-0
| 产品名称: | 1-NM-PP1 |
| CAS No.: | 221244-14-0 |
| Chemical Name: | 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | PP1 Analog II |
| 分子量: | 331.41 |
| 分子式: | C₂₀H₂₁N₅ |
| SMILES: | CC(N1N=C(CC2=CC=CC3=C2C=CC=C3)C4=C(N)N=CN=C41)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 1-NM-PP1，细胞渗透性 PP1 类似物，是一种有效的Src家族激酶抑制剂，对 v-Src-as1 与 c-Fyn-as1 的IC50值分别为 4.3 nM、3.2 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bishop, A.C., Kung, C.y., Shah, K., et al.Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approachJ. Am. Chem. Soc.121(4),627-631(1999)
Bishop, A.C., Ubersax, J.A., Petsch, D.T., et al.A chemical switch for inhibitor-sensitive alleles of any protein kinaseNature407(6802),395-401(2000)
Weiss, E.L., Bishop, A.C., Shokat, K.M., et al.Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4pNat. Cell Biol.2(10),677-685(2000)
Ira, G., Pellicioli, A., Balijja, A., et al.DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Nature431(7011),1011-1017(2004)
Larochelle, S., Merrick, K.A., Terret, M.E., et al.Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cellsMol. Cell25(6),839-850(2007)
Van den Broeke, C., Radu, M., Deruelle, M., et al.Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinasesProc. Natl. Acad. Sci. USA106(21),8707-8712(2009)
