Dubermatinib
Cat. No.：YN440233
CAS No. ：1341200-45-0
规格
价格(RMB)
库存
| 产品名称: | Dubermatinib |
| CAS No.: | 1341200-45-0 |
| Chemical Name: | 2-[[5-chloro-2-[[4-[(4-methyl-1-piperazinyl)methyl]phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl-benzenesulfonamide |
| Synonyms: | TP-0903 |
| 分子量: | 516.06 |
| 分子式: | C₂₄H₃₀ClN₇O₂S |
| SMILES: | O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=NC=C2Cl)(N(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dubermatinib (TP-0903) 是具有高效性和选择性的Axl受体酪氨酸激酶抑制剂，IC50值为27 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mollard, A., Warner, S.L., Call, L.T., et al.Design, synthesis and biological evalutation of a series of novel Axl kinase inhibitorsACS Med. Chem. Lett.2(12),907-912(2011)
Mangelson, R., Peterson, P., Foulks, J.M., et al.Abstract 2197: The AXL kinase inhibitor, TP-0903, demonstrates efficacy in preclinical models of colorectal cancer independent of KRAS mutation statusCancer Res.79(13 Suppl),(2019)
