SGI-7079
Cat. No.：YN440234
CAS No. ：1239875-86-5
规格
价格(RMB)
库存
| 产品名称: | SGI-7079 |
| CAS No.: | 1239875-86-5 |
| Chemical Name: | 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-benzeneacetonitrile |
| Synonyms: | SGI-7079,SGI 7079,SGI7079 |
| 分子量: | 455.53 |
| 分子式: | C₂₆H₂₆FN₇ |
| SMILES: | N#CCC1=CC=CC(C2=C3C(NC=C3C)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGI-7079是一种Axl抑制剂, 显著抑制 SUM149 和 KPL-4 细胞增殖, IC50 分别为0.43 和 0.16 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wang, X., Saso, H., Iwamoto, T., et al.TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinaseCancer Res.73(21),6516-6525(2013)
Byers, L.A., Diao, L., Wang, J., et al.An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceClin. Cancer Res.19(1),279-290(2013)
