Bemcentinib
Cat. No.：YN440308
CAS No. ：1037624-75-1
规格
价格(RMB)
库存
| 产品名称: | Bemcentinib |
| CAS No.: | 1037624-75-1 |
| Chemical Name: | 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5Hbenzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine |
| Synonyms: | R428; BGB324 |
| 分子量: | 506.64 |
| 分子式: | C₃₀H₃₄N₈ |
| SMILES: | NC1=NC(NC2=CC(CC[C@@H](N3CCCC3)CC4)=C4C=C2)=NN1C(N=N5)=CC6=C5C7=CC=CC=C7CCC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bemcentinib (R428) 是一种高效的具有选择性的Axl抑制剂，IC50值为 14 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Holland, S.J., Pan, A., Franci, C.R., et al.R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancerCancer Res.70(4),1544-1554(2010)
Brand, T.M., Iida, M., Stein, A.P., et al.AXL is a logical molecular target in head and neck squamous cell carcinomaClin. Cancer Res.21(11),2601-2612(2015)
Jin, C.-w., Wang, H., Chen, Y.-q., et al.Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathwayCell. Physiol. Biochem.35(3),1151-1166(2015)
Meertens, L., Labeau, A., Dejarnac, O., et al.Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responsesCell Rep.18(2),324-333(2017)
