Asciminib
Cat. No.：YN440090
CAS No. ：1492952-76-7
规格
价格(RMB)
库存
| 产品名称: | Asciminib |
| CAS No.: | 1492952-76-7 |
| Chemical Name: | N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-3-pyridinecarboxamide |
| Synonyms: | ABL001 |
| 分子量: | 449.84 |
| 分子式: | C₂₀H₁₈ClF₂N₅O₃ |
| SMILES: | O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asciminib (ABL001) 是一种有效和选择性的变构BCR-ABL1抑制剂，抑制 Ba/F3 细胞生长的 IC50值为 0.25 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wylie, A.A., Schoepfer, J., Jahnke, W., et al.The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1Nature543(7647),733-737(2017)
Schoepfer, J., Jahnke, W., Berellini, G., et al.Discovery of asciminib (ABL001), an allosteric inhibitor of the tyrosine kinase activity of BCR-ABL1J. Med. Chem.61(18),8120-8135(2018)
