AST 487
Cat. No.：YN440307
CAS No. ：630124-46-8
规格
价格(RMB)
库存
| 产品名称: | AST 487 |
| CAS No.: | 630124-46-8 |
| Chemical Name: | N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-urea |
| Synonyms: | NVP-AST487; AST 487; AST-487 |
| 分子量: | 529.56 |
| 分子式: | C₂₆H₃₀F₃N₇O₂ |
| SMILES: | O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AST 487 是一种RET激酶抑制剂，IC50为 880 nM，抑制 RET 自磷酸化，及下游效应器激活，也抑制Flt-3，IC50为 520 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Akeno-Stuart, N., Croyle, M., Knauf, J.A., et al.The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cellsCancer Res.67(14),6956-6964(2007)
Weisberg, E., Roesel, J., Bold, G., et al.Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cellsBlood112(13),5161-5170(2008)
