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Imatinib Mesylate

Cat. No.:YN440411

  • CAS No. :220127-57-1

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    • 产品名称: Imatinib Mesylate
      CAS No.: 220127-57-1
      Chemical Name: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, monomethanesulfonate
      Synonyms:甲磺酸伊马替尼; STI571 Mesylate; CGP-57148B Mesylate
      分子量:589.71
      分子式:C₃₀H₃₅N₇O₄S
      SMILES:O=S(O)(C)=O.O=C(NC1=CC=C(C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Imatinib Mesylate (STI571 Mesylate) 是一种酪氨酸激酶抑制剂,可抑制c-Kit,Bcr-Abl和PDGFR(IC50=100 nM)。
      IC50和靶点:
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    • Heinrich, M.C., Griffith, D.J., Druker, B.J., et al.Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitorBlood96(3),925-932(2000)

      Buchdunger, E., Zimmermann, J., Mett, H., et al.Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivativeCancer Res.56(1),100-104(1996)

      Wisniewski, D., Lambek, C.L., Liu, C., et al.Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinasesCancer Res.62(15),4244-4255(2002)

      Wolff, N.C., Veach, D.R., Tong, W.P., et al.PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemiaBlood105(10),3995-4003(2005)

      Coleman, C.M., Sisk, J.M., Mingo, R.M., et al.Abelson kinase inhibitors are potent inhibitors of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus fusionJ. Virol.90(19),8924-8933(2016)

      Sisk, J.M., Frieman, M.B., and Machamer, C.E.Coronavirus S protein-induced fusion is blocked prior to hemifusion by Able kinase inhibitorsJ. Gen. Virol.99(5),619-630(2018)

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