Flumatinib
Cat. No.：YN440295
CAS No. ：895519-90-1
规格
价格(RMB)
库存
| 产品名称: | Flumatinib |
| CAS No.: | 895519-90-1 |
| Chemical Name: | 4-[(4-methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)-benzamide |
| Synonyms: | HHGV678 |
| 分子量: | 562.59 |
| 分子式: | C₂₉H₂₉F₃N₈O |
| SMILES: | O=C(NC1=CC(NC2=NC=CC(C3=CC=CN=C3)=N2)=C(C)N=C1)C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Flumatinib (HHGV678) 是一种具有口服活性的选择性Bcr-Abl抑制剂，对c-Abl，PDGFRβ和c-Kit的IC50分别为 1.2 nM，307.6 nM 和 665.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Luo, H., Quan, H., Xie, C., et al.HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistanceLeukemia24(10),1807-1809(2010)
Singh, A., and Arkin, I.T.Targeting viral ion channels: A promising strategy to curb SARS-CoV-2Pharmaceuticals (Basel)15(4),396(2022)
