Ponatinib
Cat. No.：YN440187
CAS No. ：943319-70-8
规格
价格(RMB)
库存
| 产品名称: | Ponatinib |
| CAS No.: | 943319-70-8 |
| Chemical Name: | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Synonyms: | 普纳替尼; AP24534 |
| 分子量: | 532.56 |
| 分子式: | C₂₉H₂₇F₃N₆O |
| SMILES: | CC1=C(C=C(C=C1)C(NC2=CC(C(F)(F)F)=C(C=C2)CN3CCN(CC3)C)=O)C#CC4=CN=C5N4N=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ponatinib (AP24534) 是一种有效的，具有口服活性的多靶点激酶抑制剂，抑制Abl，PDGFRα，VEGFR2，FGFR1和Src的IC50分别为 0.37 nM， 1.1 nM，1.5 nM，2.2 nM 和 5.4 nM。 |
| IC50和靶点: | [{name:"VEGFR2:1.5 nM (IC50)"},{name: "PDGFRα:1.1 nM (IC50)"},{name: "FGFR1:2.2 nM (IC50)"},{name: "c-Kit:12.5 nM (IC50)"}] |
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| Solvent & Solubility: |
O'Hare, T., Shakespeare, W.C., Zhu, X., et al.AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistanceCancer Cell16(5),401-412(2009)
