CAN508
Cat. No.：YN290009
CAS No. ：140651-18-9
| 产品名称: | CAN508 |
| CAS No.: | 140651-18-9 |
| Chemical Name: | 4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol |
| Synonyms: | |
| 分子量: | 218.22 |
| 分子式: | C₉H₁₀N₆O |
| SMILES: | OC1=CC=C(/N=N/C2=C(N)NN=C2N)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAN508 是一种有效的、ATP 竞争性抑制CDK9/cyclin T1，IC50为 0.35 μM。CAN508 对 CDK9/cyclin T1 比对其他的 CDK/cyclin 高出 38 倍的选择性。CAN508 具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"CDK9/cyclinT1:0.35 μM (IC50)"},{name: "CDK2/cyclinE:20 μM (IC50)"},{name: "cdk2/cyclin A:69 μM (IC50)"},{name: "Cdk4/cyclin D1:13.5 μM (IC50)"},{name: "CDK7/cyclin H:26 μM (IC50)"},{name: "Cdk1/cyclin B:44 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Krystof, V., Cankar, P., Frysová, I., et al.4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effectsJ. Med. Chem.49,6500-6509(2006)
