Ribociclib succinate
Cat. No.：YN290371
CAS No. ：1374639-75-4
| 产品名称: | Ribociclib succinate |
| CAS No.: | 1374639-75-4 |
| Chemical Name: | butanedioic acid, compd. with 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Synonyms: | 瑞博西尼琥珀酸盐; LEE011 succinate |
| 分子量: | 552.63 |
| 分子式: | C₂₇H₃₆N₈O₅ |
| SMILES: | O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5.OC(CCC(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ribociclib succinate (LEE011 succinate) 是一种高度特异性的CDK4/6抑制剂，IC50值分别为 10 nM 和 39 nM，对 cyclin B/CDK1 复合体的活性低于其 1000 倍。 |
| IC50和靶点: | [{name:"CDK4:10 nM (IC50)"},{name: "CDK6:39 nM (IC50)"}] |
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Chen, P., Lee, N.V., Hu, W., et al.Spectrum and degree of CDK drug interactions predicts clinical performanceMol. Cancer Ther.15(10),2273-2281(2016)
Wong, C.-H., Ma, B.B.Y., Hui, C.W.C., et al.Preclinical evaluation of ribociclib and its synergistic effect in combination with alpelisib in non-keratinizing nasopharyngeal carcinomaSci. Rep.8(1),8010(2018)
