Palbociclib
Cat. No.：YN290484
CAS No. ：571190-30-2
| 产品名称: | Palbociclib |
| CAS No.: | 571190-30-2 |
| Chemical Name: | 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one; PD 0332991; PD 332991; |
| Synonyms: | 帕博西尼; PD 0332991 |
| 分子量: | 447.53 |
| 分子式: | C₂₄H₂₉N₇O₂ |
| SMILES: | O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Palbociclib (PD 0332991) 是选择性的CDK4和CDK6抑制剂，IC50分别为11 nM，16 nM。Palbociclib 有潜力用于 ER 阳性和 HER2 阴性乳腺癌的研究。 |
| IC50和靶点: | [{name:"Cdk4/cyclin D3:9 nM (IC50)"},{name: "Cdk4/cyclin D1:11 nM (IC50)"},{name: "Cdk6/cyclin D2:16 nM (IC50)"},{name: "DYRK1A:2000 nM (IC50)"},{name: "MAPK:8000 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)
