BMS-265246
Cat. No.：YN290342
CAS No. ：582315-72-8
| 产品名称: | BMS-265246 |
| CAS No.: | 582315-72-8 |
| Chemical Name: | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone |
| Synonyms: | BMS265246 |
| 分子量: | 345.34 |
| 分子式: | C₁₈H₁₇F₂N₃O₂ |
| SMILES: | CC1=CC(F)=C(C(C2=CN=C(NN=C3)C3=C2OCCCC)=O)C(F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-265246是CDK1/2抑制剂，对CDK1/cyclin B和CDK2/cyclin E的IC50分别为6 nM和9 nM。 |
| IC50和靶点: | [{name:"CDK1/cycB:6 nM (IC50)"},{name: "CDK2/Cyc E:9 nM (IC50)"},{name: "CDK4/cycD:230 nM (IC50)"}] |
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| Solvent & Solubility: |
Bettayeb, K., Baunbaek, D., Delehouze, C., et al.CDK inhibitors roscovitine and CR8 trigger Mcl-I down-regulation and apoptotic cell death in neuroblastoma cellsGenes Cancer1(4),369-380(2010)
Misra, R.N., Xiao, H., Rawlins, D.B., et al.1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-Difluorophenacyl analoguesBioorg. Med. Chem. Lett.13(14),2405-2408(2003)
Sutherland, J.J., Low, J., Blosser, W., et al.A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulatorsMol. Cancer Ther.10(2),242-254(2011)
