Ribociclib D6
Cat. No.：YN290373
| 产品名称: | Ribociclib D6 |
| CAS No.: | 1328934-40-2 |
| Chemical Name: | 7-Cyclopentyl-N,N-di(methyl-d3)-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide; Ribociclib-d6 |
| Synonyms: | LEE011 D6 |
| 分子量: | 440.57 |
| 分子式: | C₂₃H₂₄D₆N₈O |
| SMILES: | O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C([2H])([2H])[2H])C([2H])([2H])[2H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ribociclib D6 (LEE011 D6) 是 Ribociclib 的一种氘代化合物。Ribociclib 是一种高度特异性的CDK4/6抑制剂，IC50值分别为 10 nM 和 39 nM，对 cyclin B/CDK1 复合体的活性低于其 1000 倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kim, S., et al.: Mol. Cancer Ther., 12, PR02 (2013)
Rader, J., et al.: Clin. Cancer Res., 19, 6173 (2013)
