Simurosertib
Cat. No.：YN290021
CAS No. ：1330782-76-7
| 产品名称: | Simurosertib |
| CAS No.: | 1330782-76-7 |
| Chemical Name: | 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-thieno[3,2-d]pyrimidin-4(3H)-one |
| Synonyms: | TAK-931 |
| 分子量: | 341.43 |
| 分子式: | C₁₇H₁₉N₅OS |
| SMILES: | O=C1C2=C(C=C(C3=CNN=C3C)S2)NC([C@H]4N(CC5)CCC5C4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Simurosertib (TAK-931) 是一种具有口服活性，选择性， ATP 竞争性的细胞分裂周期 7 (CDC7) 激酶抑制剂，IC50为 <0.3 nM。Simurosertib 具有抗癌活性。 |
| IC50和靶点: | [{name:"Cdc7:<0.3 nM (IC50)"}] |
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| Solvent & Solubility: |
Kurasawa, O., Miyazaki, T., Homma, M., et al.Discovery of a novel, highly potent, and selective thieno[3,2- d]pyrimidinone-based cdc7 inhibitor with a quinuclidine moiety (tak-931) as an orally active investigational antitumor agentJ. Med. Chem.63(3),1084-1104(2020)
Iwai, K., Nambu, T., Dairiki, R., et al.Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitorSci. Adv.5(5),eaav3660(2019)
