Trilaciclib hydrochloride
Cat. No.：YN290031
CAS No. ：1977495-97-8
| 产品名称: | Trilaciclib hydrochloride |
| CAS No.: | 1977495-97-8 |
| Chemical Name: | 7′,8′-dihydro-2′-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-spiro[cyclohexane-1,9′(6′H)-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, dihydrochloride |
| Synonyms: | G1T28 hydrochloride |
| 分子量: | 519.47 |
| 分子式: | C₂₄H₃₂Cl₂N₈O |
| SMILES: | O=C1C2=CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=N4)N=C3N2C6(CCCCC6)CN1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trilaciclib hydrochloride (G1T28 hydrochloride) 是CDK4/6的抑制剂，对 CDK4 和 CDK6 的IC50值分别为 1 nM 和 4 nM。 |
| IC50和靶点: | [{name:"Cdk4/cyclin D1:1 nM (IC50)"},{name: "cdk6/cyclin D3:4 nM (IC50)"}] |
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| Solvent & Solubility: |
Bisi, J.E., Sorrentino, J.A., Roberts, P.J., et al.Preclinical characterization of G1T28: A novel CDK4/6 inhibitor for reduction of chemotherapy-induced myelosuppressionMol. Cancer Ther.15(5),783-793(2016)
