Senexin B
Cat. No.：YN290044
CAS No. ：1449228-40-3
| 产品名称: | Senexin B |
| CAS No.: | 1449228-40-3 |
| Chemical Name: | 4-[[2-[6-[(4-methyl-1-piperazinyl)carbonyl]-2-naphthalenyl]ethyl]amino]-6-quinazolinecarbonitrile |
| Synonyms: | SNX2-1-165 |
| 分子量: | 450.53 |
| 分子式: | C₂₇H₂₆N₆O |
| SMILES: | N#CC1=CC2=C(NCCC3=CC=C4C=C(C(N5CCN(C)CC5)=O)C=CC4=C3)N=CN=C2C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Senexin B 是有效的，高水溶性，具有口服活性的CDK8/19抑制剂，对 CDK8 和 CDK19 的Kd值分别为 140 nM 和 80 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Roninson, I.B., Porter, D.C., and Wentland, M.P.Cdk8-cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer,(2016)
McDermott, M.S., Chumanevich, A.A., Lim, C.-U., et al.Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancerOncotarget8(8),12558-12575(2017)
Amirhosseini, M., Bernhardsson, M., Lång, P., et al.Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healingJ. Cell. Physiol.234(9),16503-16516(2019)
