(+)-Bicuculline
Cat. No.：YN360916
CAS No. ：485-49-4
| 产品名称: | (+)-Bicuculline |
| CAS No.: | 485-49-4 |
| Chemical Name: | 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one |
| Synonyms: | d-Bicuculline |
| 分子量: | 367.35 |
| 分子式: | C₂₀H₁₇NO₆ |
| SMILES: | O=C1O[C@@H]([C@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=CC=C(OCO6)C6=C51 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (+)-Bicuculline 是对光敏感的GABA-A 受体竞争型拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Karobath, M., and Sperk, G.Stimulation of benzodiazepine receptor binding by γ-aminobutyric acidProc. Natl. Acad. Sci. USA76(2),1004-1006(1979)
Ueno, S., Bracamontes, J., Zorumski, C., et al.Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptorJ. Neurosci.17(2),625-634(1997)
Birnir, B., Eghbali, M., Everitt, A.B., et al.Bicuculline, pentobarbital and diazepam modulate spontaneous GABAA channels in rat hippocampal neuronsBr. J. Pharmacol.131(4),695-704(2000)
Feigenspan, A., and Weiler, R.Electrophysiological properties of mouse horizontal cell GABAA receptorsJ. Neurophysiol.92(5),2789-2801(2004)
Baram, T.Z., and Snead, O.C., IIIBicuculline induced seizures in infant rats: Ontogeny of behavioral and electrocortical phenomenaBrain Res. Dev. Brain Res.57(2),291-295(1990)
