Songorine
Cat. No.：YN360965
CAS No. ：509-24-0
| 产品名称: | Songorine |
| CAS No.: | 509-24-0 |
| Chemical Name: | (3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one |
| Synonyms: | FS145273 |
| 分子量: | 357.49 |
| 分子式: | C₂₂H₃₁NO₃ |
| SMILES: | O[C@@H](CC[C@]1(C)[C@@]2([H])C3)C42[C@@](CC5=O)([H])[C@@](C[C@]5([H])C6=C)([C@@H]6O)C3C4N(C1)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Songorine 是从乌头属中分离出的一种二萜生物碱。Songorine 是大鼠脑中的GABAA 受体拮抗剂，具有抗癌，抗心律不齐和抗炎活性。Songorine 有潜力用于上皮性卵巢癌 (EOC) 的研究。 |
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Zhao, X.-Y., Wang, Y., Li, Y., et al.Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABAA receptor antagonist in rat brainNeurosci. Lett.337(1),33-36(2003)
Zhang, H., Dong, R., Zhang, P., et al.Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathwaysOncol. Rep.41(5),3069-3079(2019)
Nesterova, Y.V., Povetieva, T.N., Suslov, N.I., et al.Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalenseBull. Exp. Biol. Med.156(5),665-668(2014)
Friese, J., Gleitz, J., Gutser, U.T., et al.Aconitum sp. alkaloids: The modulation of voltage-dependent Na+ channels, toxicity and antinociceptive propertiesEur. J. Pharmacol.337(2-3),165-174(1997)
